As part of the program EuroMir 94 Ulf Merbold and the resident crew performed a scientific research program to test organism in weightlessness and long duration missions. Ulf Merbold's experiment program included 23 life sciences, 4 materials sciences, and 3 technology experiments.

On October 11, 1994 the six cosmonauts aboard Mir were unable to activate a video camera and TV lights while recharging Soyuz TM-20's batteries. A short circuit had disabled the computer which guided Mir's solar arrays, forcing the station to drain its batteries. The cosmonauts used reaction control thrusters on the Soyuz TM-spacecraft docked to the station to orient it so its solar arrays would point toward the Sun, and switched on a backup computer. Normal conditions were restored by October 15, 1994.

Ground teams rescheduled Ulf Merbold's experiments to allow completion of those interrupted by the power problems, and moved experiments using large amounts of electricity to the end of Ulf Merbold's stay. In addition, the Czech-built CSK-1 furnace malfunctioned, forcing postponement of five of Ulf Merbold's experiments until after his return to Earth.

On November 03, 1994 Talgat Musabayev, Yuri Malenchenko, and Ulf Merbold undocked in Soyuz TM-19 and backed 190 m from Mir. They then activated the Kurs automatic approach system, which successfully redocked the spacecraft. The cosmonauts then transferred back to Mir. The test was related to the difficulties Soyuz TM-20 and Progress M-24 experienced during their automatic approaches. Final undocking and reentry the following day occurred without incident.

On November 04, 1994 Ulf Merbold again squeezed into the Soyuz TM-19 descent module, together with the Mir-16 crew of Yuri Malenchenko and Talgat Musabayev, and 16 kg of the life sciences samples he collected during his stay on the station. Additional samples - including materials processing samples to be produced when the Mir-17 cosmonauts carry out the experiments Ulf Merbold was to have conducted during his stay - were to be returned to Earth by Space Shuttle Atlantis in mid-1995. Soyuz TM-19 undocking, deorbit burn, reentry, and landing occurred without significant incident.

The freighter Progress M-25 blasted off from Baikonur on November 11, 1994 at 07:21 UTC for a flight of two days to the Mir station.
On November 13, 1994 Progress M-25 arrived. Aleksandr Viktorenko stood by at the remote-control panel on Mir during approach, but manual intervention was unnecessary. Valeri Polyakov, veteran of the Progress M-24 problems, called Progress M-25 "an ideal freighter". Among other cargoes, Progress M-25 delivered replacement parts for the failed CSK-1 materials processing furnace.
Progress M-25 docked with Mir on November 13, 1994 at 09:04:29 UTC, undocked on February 16, 1995 at 13:03:00 UTC and was destroyed in reentry on February 16, 1995 at 16:45:00 UTC.

Space Shuttle STS-63 'Discovery' performed the first rendezvous maneuver with the Mir space station.