Spacelab was a reusable laboratory used on certain spaceflights flown by the Space Shuttle. The laboratory comprised multiple components, including a pressurized module, an unpressurized carrier and other related hardware housed in the Shuttle's cargo bay. The components were arranged in various configurations to meet the needs of each spaceflight.

Spacelab components flew on 22 Shuttle missions between November 1983 and April 1998. Spacelab allowed scientists to perform experiments in microgravity in Earth orbit.

The mission carried the first Atmospheric Laboratory for Applications and Science (ATLAS-1) on Spacelab pallets mounted in the orbiter's cargo bay. The non-deployable payload, equipped with 12 instruments from the U.S., France, Germany, Belgium, Switzerland, the Netherlands and Japan, conducted studies in atmospheric chemistry, solar radiation, space plasma physics and ultraviolet astronomy. ATLAS-1 instruments were: Atmospheric Trace Molecule Spectroscopy (ATMOS); Grille Spectrometer; Millimeter Wave Atmospheric Sounder (MAS); Imaging Spectrometric Observatory (ISO); Atmospheric Lyman-Alpha Emissions (ALAE); Atmospheric Emissions Photometric Imager (AEPI); Space Experiments with Particle Accelerators (SEPAC); Active Cavity Radiometer (ACR); Measurement of Solar Constant (SOLCON); Solar Spectrum (SOLSPEC); Solar Ultraviolet Spectral Irradiance Monitor (SUSIM); and Far Ultraviolet Space Telescope (FAUST). Other payloads included Shuttle Solar Backscatter Ultraviolet (SSBUV) experiment, one get-away Special (GAS) experiment and six mid-deck experiments.