The seventh Mir docking mission continued the presence of a U.S. astronaut on the Russian space station with the transfer of physician David A. Wolf to Mir. Wolf became the sixth U.S. astronaut in succession to live on Mir to continue Phase 1B of the NASA/Russian Space Agency cooperative effort. However, the difficulties encountered by Foale and his predecessor aboard Mir, Jerry Linenger, had resulted in intense political pressure on NASA. The final decision between the termination of NASA crewing of Mir with Foale's departure, or his scheduled replacement by David Wolf was only made by NASA Administrator Daniel Goldin the night before the launch of STS-86.

Foale returned to Earth after spending 145 days in space, 134 of them aboard Mir. His estimated mileage logged was 58 million miles (93 million kilometers), making his the second longest U.S. space flight, behind Shannon Lucid's record of 188 days. His stay was marred by a collision on 25 June between a Progress resupply vehicle and the station's Spektr module, damaging a radiator and one of four solar arrays on Spektr. The mishap occurred while Mir 23 Commander Vasili Tsibliev was guiding the Progress capsule to a manual docking and depressurized the station. The crew sealed the hatch to the leaking Spektr module, leaving inside Foale's personal effects and several NASA science experiments, and repressurized the remaining modules.

An internal space walk by Tsibliev and Mir 23 Flight Engineer Aleksandr Lazutkin was planned to reconnect power cables to the three undamaged solar arrays, but during a routine medical exam 13 July Tsibliev was found to have an irregular heartbeat. Foale then began training for the space walk, but during one of the training exercises a power cable was inadvertently disconnected, leaving the station without power. On 21 July, it was announced that the internal space walk would not be conducted by the Mir 23 crew but their successors on Mir 24. On 30 July, NASA announced that Wendy Lawrence, originally assigned to succeed Foale on Mir, was being replaced by Wolf. The change was deemed necessary to allow Wolf to act as a backup crew member for the space walks planned over the next several months to repair Spektr. Unlike Wolf, Lawrence could not fit in the Orlan suit that is used for Russian space walks and she did not undergo space walk training.

Following their arrival at the station 7 August, Mir 24 Commander Anatoly Solovyev and Flight Engineer Pavel Vinogradov conducted the internal space walk inside the depressurized Spektr module 22 August, reconnecting 11 power cables from the Spektr's solar arrays to a new custom-made hatch for the Spektr. During the space walk, Foale remained inside the Soyuz capsule attached to Mir, in constant communication with the cosmonauts as well as ground controllers.

On 5 September, Foale and Solovyev conducted a six-hour external extravehicular activity to survey damage outside Spektr and to try to pinpoint where the breach of the module's hull occurred. Two undamaged arrays were manually repositioned to better gather solar energy, and a radiation device left previously by Jerry Linenger was retrieved.