STS-1 was the first orbital flight of NASA Space Shuttle Programme. Space Shuttle Columbia launched on 12 April 1981, and returned to Earth on 14 April, having orbited the Earth 37 times during the 54.5-hour mission. It was the first American manned space flight since the Apollo- Soyuz Test Project on 15 July 1975. STS-1 was also the only US manned maiden test flight of a new spacecraft system, although it was the culmination of atmospheric testing of the Space Shuttle Orbiter.

During the original planning stages for the early Space Shuttle missions, NASA management felt a need to undertake initial tests of the system prior to the first orbital flight. To that end, they suggested that STS-1, instead of being an orbital flight, be used to test the Return To Launch Site (RTLS) abort scenario. This involved an abort being called in the first few moments after launch, and using its main engines, once the SRBs had been jettisoned, to power it back to the launch site. This scenario, while potentially necessary in the event of an early abort being called, was seen as being extremely dangerous and, as a consequence, Young overruled the proposal, and STS-1 went ahead as the first orbital mission. The NASA managers were swayed by Young questioning the need for the test, and the weight of his opinion was especially strong as he was someone who not only had been to the moon twice, but had walked on it. He would fly the Shuttle again on the STS-9 mission, a ten-day flight in 1983.