STS-105 was a mission of the Space Shuttle Discovery to the International Space Station, launched from Kennedy Space Centre, Florida, 10 August 2001. This mission was Discovery's final mission until STS-114, because Discovery was grounded for a refit, and then all Shuttles were grounded in the wake of the Columbia disaster. The refit included an update of the flight deck to the glass cockpit layout, which was already in use on the Space Shuttle Atlantis.

Command Pilot: Scott J. Horowitz (Fourth Space Flight)
Pilot: Frederick W. Sturckow (Second Space Flight)
Mission Specialist 1: Daniel T. Barry (Third Space Flight)
Mission Specialist 2: Patrick G. Forrester (First Space Flight)
Mission Specialist 3: Frank L. Culbertson Jr. (Third Space Flight)
ISS Commander - Expodition 3
Mission Specialist 3: Yury V. Usachev, RKA (Fourth Space Flight)
ISS Commander - Expedition 2
Mission Specialist 4: Mikhail Turin, RKA (First Space Flight)
ISS Flight Engineer - Expedition - 3
Mission Specialist 4: James S. Voss (Fifth Space Flight)
ISS Flight Engineer - Expedition 2
Mission Specialist 5: Vladimir N. Dezhurov, RKA (Second Space Flight)
ISS Soyuz Commander - Expedition 3
Mission Specialist 5: Susan J. Helms (Fifth Space Flight)
ISS Science Officer - Expedition 2